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Tolani E
Cleveland Diagnostics
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Protein concentration is not necessarily cancer-specific
We're developing technology to evaluate the changes to the structure of the protein biomarker. These structural changes directly relate to cancer mutations. In contrast to looking at gene mutations (which evaluates your risk of getting a disease), our technology provides direct information about the onset or progression of that disease.
SIA: Simple, elegant & robust
The basis of solvent interaction analysis (or SIA) is the separation of proteins with distinct physiochemical properties by a biphasic system. Two distinct immiscible solvent systems arise when polymers and salts are mixed in water.
Separation based on structural change
A sample is first placed in the aqueous two-phase system. The system is agitated and then centrifuged to thoroughly mix and then separate the solutes. All protein isoforms partition unequally between the top and bottom phases based on their structure and interaction with other proteins.
K value*
Our SIA technology reports a quantitative ratiometric parameter that is independent of the absolute expression level, called K, which represents the ratio of the biomarker concentration in a customized biphasic solution. The value of K is used as standard cut-off clinical parameters once calibrated against known clinical samples. We measure the biomarker concentration in each of the two phases with a simple conventional technology, such as ELISA, finely tuned to detect changes in protein structure.
*K values, ratios, and graphics are for illustrative purposes only.
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3615 Superior Ave #4407B
Cleveland, OH 44114